ABSTRACT “ORALLY FAST DISSOLVING COMPOSITIONS OF NITRENDIPINE AND PROCESS OF PREPARATION THEREOF� The present invention relates to an orally fast dissolving and rapidly absorbing pharmaceutical composition of Nitrendipine which results in increased bioavailability of practically water insoluble pharmaceutical active agent and generates its rapid onset of action for the treatment of hypertension and angina pectoris. More specifically, the present invention provides a Nitrendipine formulation comprising a Nitrendipine precipitate having water solubility between 40 to 50 µg/mL and particle size ranging from 500 nm to 2000 nm, in a concentration range from 1 to 5% w/w exhibiting enhanced Cmax value in the range from 9 µg/ml to 10 µg/mL within 40 to 55 minutes. This orally fast dissolving and rapidly absorbing pharmaceutical compositions are formulated to promote the rapid dissolution, pregastric absorption of drug which bypasses the liver and minimizes extensive first pass hepatic metabolism and thus increases the bioavailability of orally administered Nitrendipine.
