Thiele, Dennis J.,Neef, Daniel W.,Mendoza, Jose S.
申请号：
AU2016204100
公开号：
AU2016204100A1
申请日:
2016.06.17
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
#$%^&*AU2016204100A120160707.pdf#####COMPOSITIONS AND METHODS RELATING TO HEAT SHOCK TRANSCRIPTION FACTOR ACTIVATING COMPOUNDS AND TARGETS THEREOF Abstract 4 -A 03WUJ Fkgumr 4 The present invention relates to HSF activating compounds, methods for their discovery, and their research and therapeutic uses, as well as pharmaceutic ally acceptable salts, solvates, chelates, non-covalent complexes, prodrugs, mixtures (including both Rand S enantiomeric forms and racemic mixtures thereof), and pharmaceutical Formulations thereof. In particular, the present invention provides compounds capable of facilitating HSF1 homotrimerization, and methods of using such compounds as therapeutic agents to treat a number of conditions associated with irregular HSF 1 activity.
