A device for splitting a pill comprising a pill splitter, including a base slidingly engaged with a jaw. The base and the jaw each include a cutting edge. The jaw slidingly engages to the base to permit the jaw and base to slide and allow the cutting edge of the jaw and the base to split a pill. A lid pivotally engages to the pill splitter to retain the pill within an interior space while two or more flexible guides positioned on a pair of central portions retain the pill in a suitable position to split the pill via the cutting edge. The suitable position of the guides is achieved via a plurality of levers to retain the pill in a central region of the pill splitter.