LAU, Johnson Yiu-Nam,CHEN, Honglin,ZHENG, Min,WANG, Pui,YUEN, Kwok Yung
申请号：
EP17786481
公开号：
EP3445398A4
申请日:
2017.04.18
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
Compositions and methods are provided for a live, attenuated influenza vaccine suitable for nasal administration. The vaccine utilizes a cold adapted influenza virus that lacks virulence factor, and includes mutations that provide replicative ability sufficient for vaccine manufacture. Vaccines so produced provide significant cross protection for non-vaccinating strains. The vaccine is safe for children under the age of 2 and adults over 49 years of age. In addition, the cold adapted, virulence factor deleted influenza virus can be adapted to provide immunity to non-influenza pathogens.
