SCHUDOK, MANFRED,WAGNER, MICHAEL,BAUER, ARMIN,KOHLMANN, ANNA
申请号：
PL07725450
公开号：
PL2032535T3
申请日:
2007.05.23
申请国别(地区):
PL
年份:
2013
代理人:
摘要：
Substituted heterocyclic spiro compound (I), is new. Substituted heterocyclic spiro compound of formula (I), is new. Either Ring A, Ring B : saturated or partially saturated 3-11C cycloalkyl (optionally substituted), 3-11 membered heterocycle containing 1-4 heteroatoms of O, S or N (where the heterocycle is unbridged, bridged or annealed, and according to ring size, the cycloalkyl is optionally substituted)； or Ring A-B : spiro compound； X : e.g. covalent bond, -O- or -S-； Y1 : e.g. covalent bond, -C(O)-, -S(O)-, -S(O 2)-, -C(NR1)-, -C(S)-, -C(=N-CN)-, -C(=CHNO 2)- or -CH(CF 3)-； R1 : H, -(1-4C)-alkyl or -(0-4C)-alkylen-(3-6C)-cycloalkyl； either R2, R3 : e.g. H, -(1-10C)-alkyl, -(1-6C)-fluoroalkyl, -(0-4C)-alkylen-(3-8C)-cycloalkyl or -(0-4C)-alkylen-aryl (optionally substituted), -(0-4C)-alkylen-Het (where Het is optionally substituted)； or CR2R3 : 3-6 membered cycloalkyl ring (optionally substituted) or 3-6 membered heterocycloalkyl ring (optionally substituted)； Z : -N(R26)-(C(R24)(R25)) m-CN； R26 : H, -(1-4C)-alkyl or -(0-4C)-alkylene-(3-6C)-cycloalkyl； either R24, R25 : e.g. H, -(1-6C)-alkyl, -(0-4C)-alkylene-(3-6C)-cycloalkyl, -(1-3C)-fluoroalkyl, -(0-4C)-alkylene-aryl (where aryl is optionally substituted) or -(0-4C)-alkylen-Het (where Het is optionally substituted)； or CR24R25 : 3-6 membered cycloalkyl ring (optionally substituted) or 3-6 membered cycloalkyl ring (optionally substituted)； and m : 1-3. Full Definitions are given in the DEFINITIONS (Full Definitions) Field. An independent claim is included for the preparation of (I). [Image] ACTIVITY : Osteopathic； Antiallergic； Neuroprotective； Nootropic； Anticoagulant； Thrombolytic； Antiasthmatic； Antiarteriosclerotic； Immunosuppressive； Virucide； Antibacterial； Hemostatic； Vasotropic； Anticonvulsant； Antiinflammatory； Gastrointestinal-Gen； Antidiabetic； Respiratory-Gen； Gynecological； Nephrotropic； Metabolic； Antithyroid； CNS-Gen； Hepatotropic； Anti-HIV； Cytostatic； Dermatological； Antimalarial； Anabolic； M
