Francis S. Lee,Barbara Hempstead,James Kocsis,Kevin Bath
申请号：
US12999581
公开号：
US08853279B2
申请日:
2009.06.16
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention relates to a method for determining whether a patient suffering from a condition that is susceptible to treatment with a compound that activates the brain serotonin system is susceptible or resistant to treatment with the compound. The method includes establishing whether the patient is a pre-adult, a transition age patient, or an adult and observing whether the genome of the patient contains at least one copy of a BDNF allele having a genetic alteration. The method further includes correlating the presence of the allele containing the genetic alteration with susceptibility or resistance of the patient to the treatment with the compound, wherein a pre-adult patient containing the genetic alteration is correlated as being susceptible to the treatment a transition age patient containing the genetic alteration is correlated as being susceptible or resistant to the treatment and an adult patient containing the genetic alteration is correlated as being resistant to the treatment.
