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METHOD FOR RELATED THERAPY WITH APPLICATION OF THEOPHYLLINE AND FEBUKSOSTAT
专利权人:
ИНК. (US);ТАКЕДА ФАРМАСЬЮТИКАЛС Ю.С.А.
发明人:
ГУНАВАРДХАНА Лхану (US),НАИК Химаншу (US),ТСАИ Макс (US)
申请号:
RU2013109380/15
公开号:
RU2013109380A
申请日:
2011.09.08
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A method of treating a patient for hyperuricemia in need of such treatment, comprising the steps of: administering to a patient suffering from hyperuricemia and at least one second disease state, a therapeutically effective amount of at least one xanthine oxidoreductase inhibitor, wherein the subject also receives concomitant administration of theophylline for the treatment of at least one second disease state, and additionally, where (i) administration of at least one xanthine oxidoreductase inhibitor is not given to the patient leads to the manifestation of theophylline toxicity in the patient; and (ii) theophylline is administered in a quantitative range from 90% to about 110% of the dose of theophylline recommended by the manufacturer in the absence of administration of at least one xanthine oxidoreductase inhibitor. 2. The method of claim 1, wherein the second disease state comprises chronic obstructive pulmonary disease, bronchial asthma, chronic bronchitis, emphysema, newborn apnea, newborn bradycardia, and combinations thereof. The method of claim 1, wherein the patient further suffers from at least one third disease state, where the third disease state includes gout, arterial hypertension, chronic stable angina pectoris, renal failure, kidney stone disease, acute gouty arthritis, chronic gouty joint disease , nodular gout, urate urolithiasis, urate nephropathy, progressive kidney disease, and combinations thereof. 4. The method according to claim 1, in which the dosage amount of theophylline is in the range from about 95% to approx1. Способ лечения пациента от гиперурикемии, нуждающегося в таком лечении, включающий стадии:введение пациенту, страдающему от гиперурикемии, и, по меньшей мере, от одного второго болезненного состояния, терапевтически эффективного количества, по меньшей мере, одного ингибитора ксантиноксидоредуктазы, где субъект также получает сопутствующее введение теофиллина для лечения, по меньшей мере, одного второго болезненного состояния
来源网站:
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