Feng He,Stefan Peukert,Karen Marie Miller-Moslin,Naeem Yusuff,Zhuoliang Chen,Bharat Lagu
申请号：
US13905686
公开号：
US09409871B2
申请日:
2013.05.30
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates to compounds of formula I:in which L, W, X, Y, Z, m, p, R1, R2, R3, R4 and R7 are defined in the Summary of the Invention； capable of inhibiting the Hedgehog and Smo signaling pathway. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the diagnosis and treatment of pathologies relating to the Hedgehog and Smo signaling pathway, for example, tumor formation, cancer, neoplasia and non-malignant hyperproliferative disorders.
