Abstract An instrument for cutting tissue to controlled dimensions for removal of tissue specimens from remote sites in the body of a patient. The instrument has a housing and a substantially flexible shaft extending from the housing to a distal end. Suction can be municated along the shaft to the distal end for distribution across a cavity utilizing a nifold to pull tissue into the cavity against a tissue engaging of the manifold. One or more needles are extendable into the cavity to enable infusion of fluid into the tissue. A blade in the distal end is extendable over the manifold to cui the tissue held by suction in the cavity. The shape and depth of the tissue removed by the cut is in accordance with the contour of the tissue engaging surface and the size and shape of the cavity at the distal end.
