增進血管形成之組合物及方法农业专利-农业学术服务平台

专利权人:: BIOGEN IDEC MA INC.;INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)

发明人:: ROSSOMANDO, ANTHONY,安东尼　罗梭曼都,安東尼　羅梭曼都,SILVESTRE, JEAN-SEBASTIEN,珍　赛巴斯汀　希维斯崔,珍　賽巴斯汀　希維斯崔,TAMARAT, RADIA,雷迪亚　塔玛雷特,雷迪亞　塔瑪雷特,安东尼罗梭曼都,安東尼羅梭曼都,珍赛巴斯汀希维斯崔,珍賽巴斯汀希維斯崔,雷迪亚塔玛雷特,雷迪亞塔瑪雷特

摘要：: Disclosed are methods of increasing vascularization in a tissue by administering a neublastin polypeptide to a mammal exhibiting impaired or inadequate blood flow in the tissue. The methods can be used to in the treatment or prevention of a disorder characterized by impaired or inadequate blood flow or to increase vascularization in an organ that has been transplanted into a subject.本發明揭示藉由將神經胚素(neublastin)多肽投與組織中顯示血流減少或不足之哺乳動物來增進該組織中血管形成之方法。該等方法可用以治療或預防特徵為血流減少或不足之病症，或用以增進已移植至個體之器官中之血管形成。