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Vaccine composition for respiratory syncytial virus and manufacturing method thereof
专利权人:
发明人:
장준,송만기
申请号:
KR1020110107994
公开号:
KR1013667020000B1
申请日:
2011.10.21
申请国别(地区):
KR
年份:
2014
代理人:
摘要:
The present invention relates to a vaccine composition for preventing and treating respiratory diseases induced by respiratory syncytial virus (RSV), and a method for preparing same. More specifically, the present invention relates to a procaryotic cell expression vector for preparing a vaccine for treating or preventing respiratory diseases induced by RSV, the procaryotic cell expression vector comprising a nucleic acid sequence for coding a whole or a part of a peptide fragment having an amino acid 120th to 230th from an N-terminal of RSV G protein; a procaryotic cell transformant for preparing the vaccine for preventing and treating respiratory diseases induced by RSV, the procaryotic transformant being transformed by the expression vector; a method for preparing a peptide fragment of RSV G protein for the vaccine for preventing and treating respiratory diseases induced by RSV, the method using the procaryotic transformant; a vaccine composition for preventing and treating respiratory diseases induced by RSV, the vaccine composition comprising a whole or a part of the peptide fragment having an amino acid 120th to 230th from the N-terminal of the RSV G protein; and a method for preventing or treating respiratory diseases due to RSV infection, the method comprising a step for administering the vaccine composition to a subject. The vaccine comprising procaryotic cell expression RSV G protein fragment according to the present invention induces very high blood serum IgG and respiratory mucosa IgA from just two immunizations, and displays effective defense against RSV replication without showing eosinophilic immunopathological effect due to the vaccine at the time of an RSV infection. Also, the present invention has very high economic efficiency as the vaccine uses a protein purified from bacteria, and resolves the problem of stability that can result from a virus vaccine by using a purified protein fragment as the vaccine having antigenicity, thereby making the prese
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
相关发明人
송만기
장준
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