As the 1 of immunomodulator,2,4- oxadiazole derivatives农业专利-农业学术服务平台

发明人:: 帕塔伊尔．戈文丹．奈尔．萨西库玛,帕塔伊爾．戈文丹．奈爾．薩西庫瑪,穆拉里哈拉．拉马钱德拉,穆拉里哈拉．拉馬錢德拉,西塔拉马伊阿．塞提．苏达山．纳里马德帕里,西塔拉馬伊阿．塞提．蘇達山．納里馬德帕里,帕塔伊尔.戈文丹.奈尔.萨西库玛,帕塔伊爾.戈文丹.奈爾.薩西庫瑪,穆拉里哈拉.拉马钱德拉,穆拉里哈拉.拉馬錢德拉,西塔拉马伊阿.塞提.苏达山.纳里马德帕里,西塔拉馬伊阿.塞提.蘇達山.納里馬德帕里

摘要：: The present invention relates to 1,2,4- oxadiazoles and 1,2,4- thiadiazole compounds, these compounds are as the therapeutic agent for being able to suppress apoptosis 1 (PD1) signal transduction pathway. The invention further relates to the derivatives of the therapeutic agent. The invention also includes the therapeutic agents and 5 kinds of derivative whats via including inhibiting by the purposes of the immunological enhancement treatment illness of PD-1, PD-L1 or PD-L2 immunosupress signal induced, and the therapy using them.本發明涉及1,2,4‑噁二唑和1,2,4‑噻二唑化合物，這些化合物作爲能够抑制程序性細胞死亡1(PD1)信號傳導通路的治療劑。本發明還涉及所述治療劑的衍生物。本發明還包括所述治療劑和5種衍生物用於經由包括抑制由PD‑1、PD‑L1、或PD‑L2誘導的免疫抑制信號的免疫增强作用治療病症的用途，以及使用它們的療法。