The invention relates to compounds and methods for modulating one or more components of a kinase cascade. The invention also relats to substantially pure compound 1 and substantially pure compound 1 salt (e.g., compound 1 hydrochloride salt and compound 1 benzenesulfonate salt). The invention further relates to methods of preparing substantially pure compound 1 and compound 1 salts.本發明係關於用於調節激酶級聯之一或多種組分的化合物及方法。本發明亦關於實質上純化合物1及實質上純化合物1鹽(例如化合物1鹽酸鹽及化合物1苯磺酸鹽)。本發明進一步係關於製備實質上純化合物1及化合物1鹽之方法。