The invention provides an antigenic peptide targeting the extracellular, but not the intracellular, form of CETP to reduce the level of LDL (including oxLDL and other derivatives of LDL) and increase the level of HDL. Accordingly, the invention provides a CETP vaccine to overcome the low immunogenicity of CETP and for long-term inhibition of CETP activity to prevent or treat oxLDL or other LDL derivative-related diseases/symptoms.本發明提供一種靶向CETP之細胞外而非細胞內形式之抗原肽，以降低LDL(包括oxLDL及LDL其他衍生物)之含量並增加HDL之含量。因此，本發明提供一種CETP疫苗，其用於克服CETP之低免疫原性及CETP活性之長期抑制，以便預防或治療oxLDL或其他LDL衍生物相關疾病/症狀。
