BROWN, ALAN DANIEL,DE GROOT, MARCEL JOHN,MARRON, BRIAN EDWARD,RAWSON, DAVID JAMES,RYCKMANS, THOMAS,STORER, ROBERT IAN,STUPPLE, PAUL ANTHONY,SWAIN, NIGEL ALAN,WEST, CHRISTOPHER WILLIAM
申请号：
ES11746620
公开号：
ES2533065T3
申请日:
2011.07.05
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of the following formula: ** Formula ** or a pharmaceutically acceptable salt thereof, wherein: R1 is a 5- or 6-membered heteroaryl "linked by a C" comprising (a) one or two nitrogen atoms or, when it has 5 members, (b) one or two nitrogen atoms and one sulfur atom, said heteroaryl being optionally substituted on a carbon atom of the ring with F or Cl； R2, R3 and R4 are independently H, F, Cl or -OCH3； R5 is CN, F, Cl or R6； Ra is phenyl optionally substituted with one to three substituents independently selected from F, Cl or R6； Rb is H, F, Cl or R6； R6 is (C1-C4) alkyl or (C1-C4) alkyloxy, each optionally substituted with one to three F； Z1 is (a) phenyl, optionally substituted with one to three substituents independently selected from F, Cl or R6； or (b) a 5 or 6 membered heteroaryl "linked by a C" comprising one or two nitrogen atoms, said heteroaryl being optionally substituted with R7 or R8, or both R7 and R8； R7 is attached to a carbon of the Z1 ring and is selected from F, Cl, NR9R10, R6, cycloalkyl (C3-C8) or Het1； R8 is attached to a nitrogen of the ring Z1 and is selected from (C1-C4) alkyl, cycloalkyl (C3-C8) or Het1 "linked by a C"； Het1 is a 3- to 8-membered saturated monoheterocycloalkyl comprising one or two ring members selected from -NR11- and -O-, said monoheterocycloalkyl being optionally substituted on a ring carbon atom with one to three substituents independently selected from F, alkyl (C1-C6), (C1-C4) alkyloxy (C0-C4) alkylene and (C3-C8) cycloalkyl； and R9, R10 and R11 are independently selected from H, (C1-C6) alkyl or (C3-C8) cycloalkyl； or, when Het1 is "bound by an N", R11 is absent from that nitrogen atom.Un compuesto de la siguiente fórmula:**Fórmula** o una sal farmacéuticamente aceptable del mismo, en la que: R1 es un heteroarilo de 5 o 6 miembros "unido por un C" que comprende (a) uno o dos átomos de nitrógeno o, cuando tiene 5 miembros, (b) uno o dos átomos de nitrógeno y un átomo de azufre, estando dicho heteroarilo op
