Bryan E. Laulicht,Sasha H. Bakhru,Solomon S. Steiner,Edith Mathiowitz
申请号：
US16144450
公开号：
US20200129616A1
申请日:
2018.09.27
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Methods and compositions for delivering antigens to the lymphatic system in doses that desensitize patients to future exposure to antigens have been developed. Rapid desensitization is achieved by introducing small quantities of antigen into the lymphatic system. In preferred embodiments, the compositions are administered to yield therapeutically effective levels of antigen within the lymph, where macrophages reside in the greatest concentration, by intradermal administration, using for example, microneedles or microparticles, oral administration, using for example, enteric coated capsules or tablets, or autologous transfusion. In some embodiments, the methods and compositions for delivering antigens orally achieve uptake by the Peyer's patches of the small intestines.
