A COMPOSITION FOR PREVENTING OR TREATING AN RNA VIRAL INFECTION COMPRISING SAMHD1 OR A NUCLEIC ACID MOLECULE ENCODING THE SAMHD1

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专利权人:

SNU R&DB FOUNDATION

发明人:

Kwangseog AHN,Changhoon OH,Jongsu CHOI,Jeongmin RYOO

申请号：

US14649771

公开号：

US20150320842A1

申请日:

2013.01.07

申请国别(地区):

US

年份:

2015

代理人:

摘要：

The present disclosure relates to the ssRNA-specific ribonuclease activity of SAMHD1 (sterile alpha motif (SAM) domain and HD domain-containing protein 1) and its use. It is noteworthy that SAMHD1 has dual catalytic functions which are ribonuclease activity and dNTPase activity: however unlike the dNTPase activity, the ribonuclease activity of SAMHD1 did not require the cofactor dGTP. The present invention can be employed to degrade viral genomic ssRNA and to prevent or treat a ssRNA viral infection.

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中国工程科技知识中心

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