Jay Gregory Calvert,Michael G. Sheppard,Siao-Kun W. Welch,Raymond R. R. Rowland,Dal-Young Kim
申请号：
US12608305
公开号：
US08895025B2
申请日:
2009.10.29
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention provides isolated polynucleotide molecules that comprise a DNA sequence encoding an infectious RNA sequence encoding a genetically-modified North American PRRS virus, wherein the polynucleotide molecule lacks at least one detectable antigenic epitope of North American PRRS virus. The invention also provides vaccines comprising genetically modified North American PRRS virus, RNA molecules, plasmids and viral vectors comprising the isolated polynucleotide molecules. Also provided are isolated polynucleotide molecules further comprising at least one nucleotide sequence that encodes a detectable heterologous antigenic epitope, and vaccines comprising North American PRRS virus, RNA molecules, plasmids and viral vectors comprising such isolated polynucleotide molecules.
