UNIVERSITY HEALTH NETWORK (UHN); TECHNOLOGY DEVELOPMENT AND COMMERCIALIZATION
发明人:
Philippe P. MONNIER,Nardos G. TASSEW
申请号：
US14915492
公开号：
US20160271230A1
申请日:
2014.08.06
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Disclosed herein is an agent that modulates a cis interaction between Repulsive Guidance Molecule A (RGMa) and Neogenin or lipid rafts. Modulation by the agent may include blocking the cis interaction between RGMa and Neogenin and/or disrupting lipid rafts. In turn, this promotes neuronal cell survival and axon growth and/or regeneration. Also disclosed herein is a method of treating a disease in a subject in need thereof. The method may include administering the agent to the subject. Further disclosed herein is a method of identifying an agent that modulates the cis interaction between RGMa and Neogenin.
