SLEIGH JAMES WALLACE,DENNY WILLIAM ALEXANDER,JOSE JINEY,GAMAGE SWARNALATHA AKURATIYA,HARVEY MARTYN GREGORY,VOSS LOGAN JAMES
申请号：
NZ61925712
公开号：
NZ619257A
申请日:
2012.10.08
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
This disclosure relates to a family of compounds of formula (I). These are ketamine derivatives wherein Y1, Y2, X1 and X2 are as defined in the specification. The disclosure also related to pharmaceutical compositions comprising these compounds and methods of providing provide pain relief or analgesia and inducing and maintaining general anesthesia or sedation using these compounds. Examples of the compounds include: 3-((1-(2-chlorophenyl)-2-oxocyclohexyl)amino)propyl acetate, n-propyl 3-((1-(2-chlorophenyl)-2-oxocyclohexyl)amino)propanoate, ethyl4-((1-(2-chlorophenyl)-2-oxocyclohexyl)amino)butanoate, isopropyl 5-((1-(2-chlorophenyl)-2-oxocyclohexyl)amino)pentanoate and ethyl 4-((1-(2-chlorophenyl)-2-oxocyclohexyl)(methyl)amino)butanoate.
