LEE, YOUNG WOO,이영우,LIM, SAE HWAN,임세환,CHO, WAN JIN,조완진,JANG, JI YEON,장지연
申请号：
KR1020120030540
公开号：
KR1012405180000B1
申请日:
2012.03.26
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A hyaluronic acid derivative film is provided to improve strength, stability, flexibility, adhesion to biological tissues, and biocompatibility. CONSTITUTION: A hyaluronic acid derivative film comprises a polymer with a hydroxy-terminated group in a hyaluronic acid-crosslinked structure. The hyaluronic acid derivative film comprises 50-90 weight% of a hyaluronic acid and 10-50 weight% of a polymer which includes the hydroxy-terminal group. The cross-linking density of the hyaluronic acid derivative film is 1-100 mol%. The hyaluronic acid derivative is manufactured by the reaction of one between hyaluronic acid and hyaluronic salt； or hyaluronic acid or hyaluronic acid salt； and a polymer which can form an ether covalent bond with the hyaluronic acid； and an epoxide crosslinking agent. [Reference numerals] (AA) Hyaluronic acid chain； (BB) Crosslinked epoxide crosslinking agent； (CC) Hydroxy-terminal group including polymer chain； (DD) Refinement； (EE) Epoxide derivative； (FF) Epoxide derivative without hydroxy-terminal group including polymer chain하이드록시(-OH) 말단기를 포함하는 고분자와 히알루론산을 혼합한 용액에 에폭사이드 가교제를 반응하여 제조된 하이드록시(-OH) 말단기를 포함하는 고분자가 포함된 히알루론산 유도체 필름은 물리적 강도, 체내 안정성, 유연성, 생체조직에 대한 부착성 및 생체적합성을 향상시킨다.
