KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
发明人:
KANG, Jong Soon,강종순,YOON, Yeo Dae,윤여대,YUN, Ji Eun,윤지은,OH, Soo Jin,오수진,LEE, Chang Woo,이창우
申请号：
KRKR2014/007678
公开号：
WO2015/076481A1
申请日:
2014.08.19
申请国别(地区):
WO
年份:
2015
代理人:
摘要：
The present invention relates to double-stranded RNA (dsRNA) for inducing transcriptional activity of TXNIP genes and inhibiting cancer cell growth, wherein the dsRNA, which is complementary to TXNIP gene promoters, increases the transcriptional activity of TXNIP genes, which are tumor suppressor genes, in a cancer cell line and significantly inhibits cancer cell growth, and thus the dsRNA, which is complementary to the TXNIP gene promoters, can be effectively used as an active ingredient in a composition for preventing and treating cancer.La présente invention concerne un ARN double brin (ARNdb) pour induire une activité transcriptionnelle de gènes TXNIP et inhiber la croissance de cellules cancéreuses, lARNdb, qui est complémentaire de promoteurs du gène TXNIP, augmentant lactivité transcriptionnnelle des gènes TXNIP, qui sont des gènes suppresseurs de tumeur, dans une lignée de cellules cancéreuses, et inhibant dune manière significative la croissance des cellules cancéreuses, de sorte que lARNdb qui est complémentaire des promoteurs du gène TXNIP peut être efficacement utilisé en tant que principe actif dans une composition pour la prévention et le traitement du cancer.본 발명은 본 발명은 TXNIP 유전자의 전사활성 유도 및 암 세포 성장을 억제하는 dsRNA(double strand RNA)에 관한 것으로, TXNIP 유전자의 프로모터 부위에 상보적인 dsRNA는 암세포주에서 종양억제 유전자인 TXNIP 유전자의 전사활성을 증가시키고, 암세포 성장을 유의적으로 억제함으로, 상기 TXNIP 유전자의 프로모터 부위에 상보적인 dsRNA를 암 예방 및 치료용 조성물에 유효성분으로 유용하게 사용될 수 있다.
