GARCIA GONZALEZ NURIA,CARRERA CARRERA FRANCESC,JULIA JANE MONTSERRAT,DEBETHUNE LAURENT,SERRA MASIA XAVIER
申请号：
ZA201105743
公开号：
ZA201105743B
申请日:
2011.08.04
申请国别(地区):
ZA
年份:
2012
代理人:
摘要：
The present invention is directed to novel crystalline addition salts of (i) tromethamine with (ii) an azabiphenylaminobenzoic acid derivatives of formula (I) wherein R 1 is selected from the group consisting of C 1 -C 4 alkyl, C 3 -C 4 cycloalkyl and -CF 3 , G 1 is selected from nitrogen atoms and CH, C(CH 3 ) and C(CF 3 ) groups, and G 2 represents a phenyl group optionally substituted with one or two substituents selected from chloro, fluoro, methoxy, ethoxy, isopropoxy, trifluoromethoxy, CF 3 , and -CONR 7 R 8 , wherein R 7 is hydrogen and R 8 is cyclopropyl or R 7 and R 8 together with the nitrogen atom to which they are attached form a group of formula wherein n is 1. and pharmaceutically acceptable solvates thereof, and their use in the treatment, prevention or suppression of diseases susceptible to ameliorate by inhibition of dihydroorotate dehydrogenase such as autoimmune, infectious and viral diseases.
