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SUSTAINED RELEASE MICROSPHERES AND METHOD OF PRODUCING THE SAME
专利权人:
OAKWOOD LABORATORIES; LLC
发明人:
RICHEY, TRACY,THANOO, BAGAVATHIKANUN, CHITHAMBARA
申请号:
EP14762738
公开号:
EP2968184A4
申请日:
2014.03.14
申请国别(地区):
EP
年份:
2016
代理人:
摘要:
A method of making a sustained release microsphere formulation, wherein the release rate of a bioactive ingredient is manipulated by controlling the crystallinity of said bioactive ingredient, includes the steps of combining the active ingredient and an encapsulating polymer in at least one solvent, or mixtures thereof, to form a dispersed phase and processing the dispersed phase without filtering, filtering the combined dispersed phase with a hydrophobic or a hydrophilic filter, or filtering the active ingredient and encapsulating polymer individually with a hydrophobic or hydrophilic filter before combining them to form the dispersed phase. The dispersed phase is then combined with a continuous phase to form the microsphere formulation.
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中国工程科技知识中心
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