Formula I:(In formula, as for R1 low-grade alkyl,As for R2 hydrogen or low-grade alkyl,Z the low-grade alkyl which is possible to have possessed the substituent, low-grade arukeniru which is possible to have possessed the substituent, the low-grade alkoxy which is possible to have possessed amino and the substituent which are possible to have possessed the substituent, the hetero cyclic basis which is possible to have possessed the hydrocarbon cyclic basis or the substituent which is possible to have possessed the substituent) with the chemical compound which is shown without correlating with the increase and decrease of weight discovered the fact that sugar metabolism is made to improve. To use as the sugar metabolism improvement medicine it is possible the said chemical compound.式I:(式中、R1は低級アルキル、R2は水素又は低級アルキル、Zは置換基を有していてもよい低級アルキル、置換基を有していてもよい低級アルケニル、置換基を有していてもよいアミノ、置換基を有していてもよい低級アルコキシ、置換基を有していてもよい炭化水素環式基又は置換基を有していてもよいヘテロ環式基)で示される化合物が体重の増減と相関せずに糖代謝を改善させることを見出した。該化合物は、糖代謝改善剤として用いることができる。
