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צמדים של ε – פוליליסין ושימוש בהם
专利权人:
MERCK PATENT GMBH
发明人:
申请号:
IL21760312
公开号:
IL217603A
申请日:
2012.01.17
申请国别(地区):
IL
年份:
2017
代理人:
摘要:
Conjugate comprises at least one carboxyl group-containing compound and an oligomer, where the oligomer: comprises peptidically crosslinked monomer units; is formed from more than 50%, relative to the number of monomer units, of epsilon -lysine monomer units; or comprises at least 10 consecutive monomer units that are formed from at least up to 70%, relative to the number of monomer units, of epsilon -lysine monomer units. Independent claims are included for: (1) the preparation of the conjugate comprising providing the oligomers, as above per se, and conjugating at least one optionally activated carboxylic group-containing compound to the oligomer; and (2) a kit, for preparing pharmaceutical composition (preferably a therapeutic or image enhancing composition), comprising the above conjugate.
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