HEPATOPROTECTION COMPOSITION CONTAINING ECKLONIA STOLONIFERA OR ECKLONIA CAVA SPIRIT EXTRACT AND PHLOROTANNINS WHICH PREVENTS LIVER FROM ALCOHOLIC LIVER INJURY
PUKYONG NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION
发明人:
KIM, HYEUNG RAK,김형락,LEE, MIN SUP,이민섭,SHIN, TAI SUN,신태선,BYUN, DAE SEOK,변대석,CHOI, JAE SUE,최재수
申请号：
KR1020110039212
公开号：
KR1020120121308A
申请日:
2011.04.26
申请国别(地区):
KR
年份:
2012
代理人:
摘要：
PURPOSE: A hepatoprotection composition containing phlorotannins isolated from Ecklonia stolonifera or Ecklonia cava extract is provided to be used as a pharmaceutical composition for preventing and treating liver diseases.CONSTITUTION: A hepatoprotection composition which suppresses hepatocyte injury due to alcohol contains spirit extract of Ecklonia stolonifera or Ecklonia cava as an active ingredient. A health food composition for hepatoprotection contains the spirit extract of Ecklonia stolonifera or Ecklonia cava as an active ingredient. A pharmaceutical composition for hepatoprotection contains phlorotannin compounds as an active ingredient, isolated and purified from an ethyl acetate fraction of Ecklonia stolonifera or Ecklonia cava. The phlorotannin compounds are eckol, dieckol, dioxynodehydroeckol, phlorofucofuroeckol A, and phlorofucofuroeckol B.COPYRIGHT KIPO 2013[Reference numerals] (AA) Ecklonia stolonifera and Ecklonia cava (BB) Shade drying (CC) Powder (DD) Reflux extraction(repeat three times), using spirit (EE) Extraction (FF) Filtering at reduced pressure (GG) Vacuum concentration, 40°C(removing organic solvent) (HH) Crude extract of Ecklonia stolonifera and Ecklonia cava (II) Organic solvent soluble fraction(repeat 3-4 times) (JJ) N-hexane soluble extract (KK) Water soluble fraction (LL) Dichloromethane soluble extract (MM) Water soluble fraction (NN) Ethyl acetate soluble extract (OO) Water soluble fraction본 발명은 곰피 또는 감태 주정 추출물로부터 분리된 플로로탄닌류를 함유하는 알콜성 간손상에 대한 간보호용 조성물에 관한 것으로, 보다 구체적으로는 곰피 또는 감태 주정 추출물에 함유된 플로로탄닌류가 알콜에 의한 HepG2 간세포 손상에 대하여 간세포 사멸 억제효과를 갖는 간 보호용 조성물에 관한 것이다.
