CAMPBELL, William,PAULSEN, Neil,JOHNSON, Roland,HEPLER, Douglas
申请号：
ES10830669
公开号：
ES2645200T3
申请日:
2010.11.10
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A pharmaceutically acceptable composition, wherein said composition does not include viscosity enhancing celluloses or a viscosity enhancing agent selected from alginic acid, gelatin, acacia carbomer and ketostearyl alcohol or adhesive components, and is not in the form of a gel, and wherein the composition comprises a lipid carrier and at least two active agents selected from the group consisting of antibiotics, antifungals, antiparasitic, antiviral, nonsteroidal anti-inflammatory, analgesic, anesthetic and steroids for use in the treatment or prevention of an infection of an otitis externa and its sequelae by topically administering a pharmaceutically acceptable composition in the external auditory canal, the treatment or prevention comprising the application of the composition in the external auditory canal in a single dose sufficient to improve clinically or resolve the treated condition and in which the lipid carrier is an emulsion of lipid oil in water, a lipid microemulsion or a lipid vesicle and in which the lipid is selected from phospholipids, in which the lipid vesicle lipid is selected from compounds of Phosphatidyl selected from phosphatidylglycerol, phosphatidylinositol, phosphatidylcholine, preferably 1,2-diacyl-5N-glycerol-3-phosphatidyl choline, phosphatidylserine, phosphatidylethanolamine, sphingolipids, cerebrosides and gangliosides, preferably diacylphosphatidylglycerols in the lipid atoms-18 in the lipid fraction carbon, particularly between 16-18 carbon atoms, and is saturated； cardiolipins, trilinoleins, lecithins and ceramides.Una composición farmacéuticamente aceptable, en la que dicha composición no incluye celulosas mejoradoras de la viscosidad o un agente mejorador de la viscosidad seleccionado entre ácido algínico, gelatina, carbómero de acacia y alcohol cetoestearílico o componentes adhesivos, y no está en forma de un gel, y en la que la composición comprende un portador lipídico y al menos dos agentes activos seleccionados entre el gru
