The invention relates to a transdermal therapeutic system made of thefollowing layers: a carrier layer (T), an activesubstance layer (R), a membrane layer (M) and optionally an adhesive layer(K), wherein the carrier layer (T) is impenetrable tothe active substance and to water, the active substance layer (R) comprises asan active substance component the salt of an alkalireactive active substance, such as a CNS-active amine in combination with atleast one alkali reactive further component, and apolymer component (PI), wherein the active substance is released from theactive substance layer (R) only by the moistureentering from the exterior through the membrane layer (M), and the membranelayer (M) is made of a polymer component (P2),allowing a uniform delivery of basic active substances to the skin.
