The present invention relates, inter alia, to ghrelin analogues and their medical use, for example in the treatment of cachexia, chronic obstructive pulmonary disease, gastrointestinal disorders (e.g., gastroparesis and/or inflammatory disorders such as colitis, gut barrier dysfunction, and ischemia reperfusion injury), loss of body weight, and decreased appetite.本發明尤其係關於胃飢餓素(ghrelin)類似物及其於例如治療惡病質、慢性阻塞性肺病、胃腸疾病(例如胃輕癱及/或炎性疾病，諸如結腸炎、腸道屏障功能障礙及缺血性再灌注損傷)、體重損失及食慾降低中之醫學用途。
