The present invention relates to the technical field of transdermal deliveryof pharmaceuticals andcosmetic agents, such as pharmaceutical and cosmetic agents of high molecularweight. Thetransdermal delivery system comprises an ethoxylated oil or fatty acid, fattyalcohol or fatty aminehaving 10-19 ethoxylations per molecule. Through the methods and systemsdisclosed herein, onecan transdermally deliver high molecular weight pharmaceuticals and cosmeticagents to skin cells, aheretofore technically challenging task.