能夠專一地結合組織因子路徑抑制子的抗體农业专利-农业专业知识服务系统

发明人:: HILDEN, IDA,希尔登　伊达,希爾登　伊達,CLAUSEN, JES THORN,克劳森　杰斯　索恩,克勞森　傑斯　索恩,PETERSEN, LARS CHRISTIAN,彼德森　拉尔斯　克里斯堤恩,彼德森　拉爾斯　克里斯堤恩,索伦森　布瑞特　宾诺,索倫森　布瑞特　賓諾,PETERSEN, HELLE HEIBROCH,彼德森　海伦　海伯贺,彼德森　海倫　海伯賀,希尔登伊达,希爾登伊達,克劳森杰斯索恩,克勞森傑斯索恩,彼德森拉尔斯克里斯堤恩,彼德森拉爾斯克里斯堤恩,索伦森布瑞特宾诺,索倫森布瑞特賓諾,彼德森海伦海伯贺,彼德森海倫海伯賀

摘要：: The invention relates to antibodies that are capable of specifically binding tissue factor pathway inhibitor (TFPI), neutralising free TFPI and reducing the clotting time of blood. Furthermore, the invention relates to polynucleotides that encode such antibodies and to cells that comprise the polynucleotides or that express the antibodies of the invention. Such antibodies have utility in the treatment of subjects with a coagulopathy, alone as well as in combination with a second agent.本發明係關於能夠專一性結合組織因子路徑抑制子(TFPI)、中和游離的TFPI及減少血液的凝結時間的抗體。此外，本發明係關於編碼該等抗體之聚核苷酸及包含該等聚核苷酸或表現本發明之抗體的細胞。該等抗體單獨或與第二藥劑結合使用時，對有凝血病變的個體具有治療效用。