THE ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
发明人:
EVANS, GARY BRIAN,LONGSHAW, ALISTAIR IAN,SCHRAMM, VERN L.,TYLER, PETER, CHARLES
申请号:
EP10800093
公开号:
EP2454263A4
申请日:
2010.07.16
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
The present invention relates to 3-hydroxypyrrolidine compounds of the general formula (1) which are inhibitors of 5′-methylthioadenosine phosphorylase or 5′-methylthioadenosine nucleosidase. The invention also relates to the use of these compounds in the treatment of diseases or conditions in which it is desirable to in 5′-methylthioadenosine phosphorylase or 5′-methylthioadenosine nucleosidase including cancer, and to pharmaceutical compositions containing the compounds.