[ Challenge ] Lipid sustained release formulation The initial (pre-concentrate), and I provides a pharmaceutical composition further comprising a pharmacologically active substance in the sustained-release lipid initial formulation . A The present invention , a) a sorbitan unsaturated fatty acid ester of a polar head group -OH ( hydroxyl ) group is present 2 or more , b) a phospholipid , c) does not have the ionizable groups , the hydrophobic moiety Carbon and a liquid curing agent having a triacyl group or a carbocyclic ring structure having from 15 to 40 , present as a lipid liquid phase in the absence of an aqueous fluid and forming a liquid crystal in the aqueous fluid , and provides a sustained release lipid initial formulation to . [ Selection Figure ] Figure 3【課題】徐放性脂質初期製剤(pre-concentrate)、およびこの徐放性脂質初期製剤に薬理活性物質をさらに含む薬学的組成物を提供する。【解決手段】本発明は、a)極性頭部基に-OH(ヒドロキシル)基が2つ以上存在するソルビタン不飽和脂肪酸エステルと、b)リン脂質と、c)イオン化基を有せず、疎水性部分は炭素数15~40のトリアシル基または炭素環構造を有する液晶硬化剤とを含み、水性流体の不在下で脂質液相として存在し且つ水性流体上で液晶を形成する、徐放性脂質初期製剤を提供する。【選択図】 図3
