Margaret A. Wheatley,Odelia Mualem Burstein,John R. Eisenbrey,Dalia El-Sherif
申请号：
US12301423
公开号：
US09220709B2
申请日:
2007.05.21
申请国别(地区):
US
年份:
2015
代理人:
摘要：
This invention provides an improvement to methods of drug loading of ultrasound contrast agents. Echogenic drug-loaded polymer microcapsules, nanocapsules, or mixtures thereof produced by the method of the invention wherein the echogenic drug-loaded polymer microcapsules, nanocapsules, or mixtures thereof contain at least 10% more of a drug as compared to (1) echogenic drug-loaded polymer microcapsules, nanocapsules, or mixtures thereof prepared by adding drug prior to emulsifying or (2) echogenic drug-loaded polymer microcapsules, nanocapsules, or mixtures thereof prepared by adding drug to lyophilized polymer microcapsules, nanocapsules, or mixtures thereof.
