Douglas F. Nixon,Keith E. Garrison,Duncan A. Meiklejohn,Mario A. Ostrowski,R. Bradley Jones,Ashish Agrawal,Jack Lenz,Seth Rakoff-Nahoum,Frederick M. Hecht
申请号：
US13891970
公开号：
US20130323279A1
申请日:
2013.05.10
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention provides isolated HERV polypeptides and compositions, including immunogenic compositions, comprising a HERV polypeptide. The present invention provides immunogenic compositions comprising a nucleic acid comprising a nucleotide sequence encoding a HERV polypeptide. The immunogenic compositions are useful for stimulating a T cell immune response to a lentiviral peptide. The present invention further provides methods of stimulating an immune response in an individual to a retrovirus- or lentivirus-infected cell. The present invention further provides methods of treating cancers in which HERV polypeptides are expressed. Also provided are methods of treating disorders, involving decreasing an immune response to a HERV polypeptide.
