This invention regards the optical probe 1 which is suited for nonlinear optics such as medical intended two photon imaging. The said probe optical guide has the lens system 6 where is arranged firmly in the end 2a of 2 and the optical guide. In addition, optical guide the frame 3 where has the cavity for 2 and lens type 6, the frame which has the transparent window 4 in the distal (2036) edge is included inside the said probe. Optical guide 2 with lens system 6, is desirable inside the frame and way it is movement possible in cross direction, the installation and others re ru. In addition, frame 3 has the optical guide 5 around the assistance which is connected to the transparent window 4 optically. This invention is profitable in order to obtain the optical probe which has big collection efficiency considerably. The said optical probe both of the ballistic photon and the spread fluorescent photon can be applied profitably at the time of being related with two photon spectroscopy which can be used at the time of detecting the event.本発明は医療目的の二光子イメージングなどの非線形光学に適した光プローブ1に関する。該プローブは光ガイド2と、光ガイドの端部2aに強固に配置されるレンズ系6を持つ。加えて、光ガイド2及びレンズ系6のための空洞を持つ筐体3であって、その遠位端に透明窓4を持つ筐体が該プローブ内に含まれる。光ガイド2はレンズ系6と共に、筐体内に好ましくは横方向に移動可能なように取り付けられる。また、筐体3は透明窓4に光学的に接続される補助的な周辺光ガイド5を持つ。本発明は著しく大きな収集効率を持つ光プローブを得るために有利である。該光プローブは、弾道光子と拡散蛍光光子の両方がイベントの検出において使用され得る二光子分光法との関連において有利に適用され得る。
