Compositions and methods for the treatment of acne are based upon a first therapeutic agent which is one or more members selected from the group consisting of: salicylic acid, azelaic acid, adapalene, benzoyl peroxide, and antibiotics; and a second therapeutic agent which comprises a taurine species. The two agents may be present in a single preparation and applied to the skin simultaneously, or they may be present in two separate preparations and applied to the skin sequentially. The taurine species may comprise free taurine, taurine salts, taurine esters, taurine complexes, taurine conjugates and taurine precursors either singly or in combination. The composition may include a liposomal carrier. Further disclosed are specific preparations and methods used for the treatment of acne.