Referring to a combination of an anti endothelial Antibody type B receptor (EtBr) and an inhibitor of Map Kinase Antibody, where the ETBR is conjugated with cytotoxin and inhibitor of MAP kinase is an inhibitor of BRAF.The cytotoxin is a cytotoxic Agent selected from toxins such as calicheamicin and maitansinoide auristatin, Antibiotics, Enzymes, Radioactive Isotopes and nucleoliticas inhibitor of BRAF is propane sulfonic acid - 1 - {3 - [5 - (4-chlorophenyl) - 1H pyrrolo [2,3-b] carbonyl] - pyridine - 2 - 2.4 - DIF Luoro - phenyl) - amide.This combination is useful in the inhibition of tumor growth (TGI) in a subject suffering from melanomaREFERIDA A UNA COMBINACION DE UN ANTICUERPO DEL RECEPTOR ANTI-ENDOTELIAL TIPO B (ETBR) Y UN INHIBIDOR DE LA MAP QUINASA, DONDE EL ANTICUERPO ANTI-ETBR SE CONJUGA CON UNA CITOTOXINA Y EL INHIBIDOR DE LA MAP QUINASA ES UN INHIBIDOR DEL GEN BRAF. LA CITOTOXINA ES UN AGENTE CITOTOXICO SELECCIONADO DE TOXINAS TALES COMO MAITANSINOIDE, CALIQUEAMICINA Y AURISTATINA, ANTIBIOTICOS, ISOTOPOS RADIOACTIVOS Y ENZIMAS NUCLEOLITICAS EL INHIBIDOR DEL GEN BRAF ES ACIDO PROPANO-1-SULFONICO{3-[5-(4-CLOROFENIL)-1H-PIRROLO{2,3-b]PIRIDINA-3-CARBONIL]-2,4-DIFLUORO-FENIL}-AMIDA. DICHA COMBINACION ES UTIL EN LA INHIBICION DEL CRECIMIENTO TUMORAL (TGI) EN UN SUJETO QUE SUFRE DE MELANOMA
