Reusable devices, systems and methods of assembly of reusable devices comprise an inner portion designed to be reused and an outer portion designed to be disposed. The reusable inner portion is a closed, self-contained receptacle comprising a housing, which encapsulates at least an imaging device, at least one illumination source, at least one rechargeable battery, and a controller. A first end of the closed reusable inner portion is covered by an optical system, and a second end of the closed reusable inner portion comprises battery contacts. The disposable outer portion comprises at least a shell and an optical dome. The housing of the reusable inner portion is inserted into the shell, and the optical dome is attached to the shell so as to detachably seal the reusable inner portion of the in-vivo device within the disposable outer portion of the device.
