PAEZ MEIRELES, ROLANDO,派斯梅雷莱斯 罗兰多,派斯梅雷萊斯 羅蘭多,AMARO GONZALEZ, DANIEL ENRIQUE,阿马罗冈雷斯 丹尼尔,阿馬羅岡雷斯 丹尼爾,CASTRO ODIO, FIDEL RAUL,卡斯楚欧迪 菲德尔,卡斯楚歐迪 菲德爾,HERNANDEZ VALDES, YENISEL,艾尔南德巴德斯 颜尼索,艾爾南德巴德斯 顏尼索,RUIZ EST
申请号：
TW104100285
公开号：
TW201538168A
申请日:
2015.01.06
申请国别(地区):
TW
年份:
2015
代理人:
摘要：
The present invention discloses a conjugate comprising erythropoietin (EPO) and an asymmetric branched polymeric structure comprising two branches of monomethoxypolyethylene glycol (mPEG), where the molecular mass of one of these mPEG branches is between 10 kDa and 14 kDa, and the molecular mass of the other branch of mPEG is between 17 kDa and 23 kDa, as well as the pharmaceutical compositions containing it. The invention also provides a method for the preparation of pegylated EPO, wherein said protein is conjugated to an asymmetric branched polymeric structure with two branches of mPEG having the above described molecular masses.本發明揭示包含紅血球生成素(erythropoietin)(EPO)和不對稱分支聚合物結構之共軛物,以及含彼之醫藥組成物,該不對稱分支聚合物結構包含二個單甲氧基聚乙二醇(mPEG)之分支,其中這些mPEG分支的其中之一的分子質量係介於10kDa和14kDa之間,而mPEG之另一分支的分子質量係介於17kDa和23kDa之間。本發明亦提供用於製備聚乙二醇化之EPO的方法,其中該蛋白質係與具有二個具上述分子質量之mPEG分支的不對稱分支聚合物結構共軛結合。
