COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF OVARIAN CANCERS THAT ARE ASSOCIATED WITH REDUCED SMARCA4 GENE EXPRESSION OR PROTEIN FUNCTION
Douglas A. Levine,Michael F. Berger,Robert A. Soslow,Petar Jelinic
申请号：
US16237692
公开号：
US20190309371A1
申请日:
2019.01.01
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Provided are compositions and methods for the identification and treatment of ovarian cancers, such as small cell ovarian cancers, in particular small cell carcinoma of the ovary, hypercalcemic type (SCCOHT), which ovarian cancers are characterized by reduced SMARCA4 gene expression and/or protein function and, as a consequence, are sensitive to growth and/or survival inhibition by one or more compounds that restore SMARCA4 gene expression and/or protein function.
