In various embodiments, a device for treatment and/or prophylaxis of decompression illness in a subject is provided. The device includes an input port to provide venous or peritoneal access to a subject to extract blood from the subject, a blood processing stage coupled to the input port processing of the blood extracted from the subject, and an output port to provide venous, arterial or peritoneal access to infuse the processed blood back into the subject. The blood processing stage includes at least one pump, at least one bubble filter, a depressurizing module in which the blood flowing through the blood processing stage is depressurized to provoke formation of gas bubbles in the blood and their subsequent release from the blood, and a gas exchange module comprising a gas reservoir and configured to provide gas exchange between the gas reservoir and the blood flowing through gas exchange module.
