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DNA sequence that increases odorant receptor representation in the olfactory system
专利权人:
Research Foundation of the City University of New York
发明人:
Paul Feinstein,Charlotte D'Hulst
申请号:
US15749007
公开号:
US10512253B2
申请日:
2016.08.03
申请国别(地区):
US
年份:
2019
代理人:
摘要:
A genetically modified vertebrate is provided that has an enhanced sense due to an over representation of a predetermined odorant receptor. The vertebrate is genetically modified by introduction of DNA that comprises at least four sequential repeats of a sequence whose primary structure is at least 90% homologous with ACATAACTTTTTAATGAGTCT (SEQ ID NO: 1). The DNA causes a nearby odorant receptor coding sequence to be over represented in a singular gene choice fashion relative to a corresponding vertebrate that lacks the DNA.
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