Forest Laboratories Holdings Limited;Ironwood Pharmaceuticals, Inc.
发明人:
Angelika Fretzen,Steven Witowski,Alfredo Grossi,Hong Zhao,Mahendra Dedhiya,Yun Mo
申请号：
US13837631
公开号：
US20130273169A1
申请日:
2013.03.15
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr (“linaclotide”； SEQ ID NO:1) or a pharmaceutically acceptable salt thereof. The linaclotide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.
