EDWARD PAUL BOWMAN,DANIEL J. CUA,ROBERT A. KASTELEIN,KATHY LYNN MILLER,MELANIE A. KLEINSCHEK,KRISTIAN SASS BAK-JENSEN,KATIA BONIFACE,BRENT S. MCKENZIE,RENE DE WAAL MALEFETY
申请号：
BRPI0807987
公开号：
BRPI0807987A2
申请日:
2008.02.26
申请国别(地区):
BR
年份:
2014
代理人:
摘要：
Methods and compositions are provided for the treatment of immune disorders, such as autoimmune diseases, or cancers, involving combination therapy with agents that inhibit the development or maintenance of Th17cells. Treatment regimens are provided in which an antagonist of a pro-inflammatory cytokine is administered for a time sufficient to alleviate signs and symptoms of an acute phase flare-up of the autoimmune disease, or cancer, and treatment with an antagonist of IL-23 is continued for a longer time to prevent recurrence of the acute event. Antagonists of PGE2 and CD 161 are also disclosed for use in treatment of autoimmune, inflammatory and proliferative disorders.
