The present application relates to an immunoglobulin capable of binding to tyrosine-23 phosphorylated annexin A2, methods for detection said tyrosine-23 phosphorylated annexin A2 and the use of said immunoglobulin in a diagnostic or therapeutic method. The present application also relates to methods of production of an immunoglobulin capable of binding to tyrosine-23 phosphorylated annexin A2 and pharmaceutical and diagnostic compositions comprising said immunoglobulin