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DOSAGE FORM FOR DELIVERY OF THE MEDICINE IN THE BIG GI
专利权人:
ЮНИВЕРСИТИ КОЛЛЕДЖ ЛОНДОН (GB)
发明人:
БАСИТ Абдул Васех (GB),ИБЕКВЕ Валентине Чиди (GB)
申请号:
RU2012153207/15
公开号:
RU2012153207A
申请日:
2012.12.10
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A dosage form for a delayed release of a drug, comprising a particle with a core and a core coating, wherein the core includes a drug and the coating comprises a mixture of a first substance that is susceptible to exposure to colon bacteria and a second substance that has a pH threshold at approximately pH 5 or higher, wherein the first substance comprises a polysaccharide selected from the group consisting of starch, amylose, amylopectin, chitosan, chondroitin sulfate, cyclodextrin, dextran, pullulan, carrageenan, sclerogl Yukan, Chitin, Kurdulan and Levan. 2. Dosage form according to claim 1, where the polysaccharide is starch. The dosage form according to claim 1 or 2, wherein the polysaccharide is starch, comprising at least about 0.1% amylose. The dosage form according to claim 3, wherein the polysaccharide is starch, comprising at least 10%, preferably at least 15%, amylose. The dosage form according to claim 1 or 2, wherein the polysaccharide is starch, comprising up to 100% amylopectin. Dosage form according to claim 1, where the second substance is a film-forming polymer substance. The dosage form according to claim 6, where the second substance is an acrylate polymer. Dosage form according to claim 1, where the second substance is an anionic copolymer of (meth) acrylic acid and a C1-6 alkyl ether of (meth) acrylic acid. The dosage form of claim 8, wherein the second substance is an anionic copolymer of methacrylic acid and methacrylic acid methyl ester. The dosage form according to claim 9, wherein the ratio of methacrylic acid to methacrylic acid methyl ester1. Лекарственная форма с отсроченным высвобождением лекарственного средства, включающая частицу с ядром и покрытием ядра, где ядро включает лекарственное средство, а покрытие включает смесь первого вещества, которое чувствительно к воздействию бактериями толстой кишки, и второго вещества, которое имеет порог pH при приблизительно pH 5 или выше, где первое вещество включает полисахарид, выбранный из
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