EVEC INC.;NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY
发明人:
Kenzo Takada,Takashi Torashima,Masahiro Nishibori
申请号:
US14761152
公开号:
US09550825B2
申请日:
2013.12.06
申请国别(地区):
US
年份:
2017
代理人:
摘要:
The present invention provides a humanized anti-HMGB1 antibody which specifically binds to a sequence consisting of the C-terminal 8 amino acid residues (EEEDDDDE) of HMGB1 protein and is effective for treatment or prevention of various inflammatory diseases related to this protein, as well as an antigen-binding fragment thereof. The present invention also provides a pharmaceutical composition comprising such an antibody or antigen-binding fragment thereof.