ДИБАС Мохаммед И. (US),ЧОУ Кен (US),ДОНЕЛЛО Джон Е. (US),ГАРСТ Майкл Е. (US),ДЖИЛ Дэниел В. (US),ВАНГ Лиминг (US)
申请号：
RU2013116763/15
公开号：
RU2013116763A
申请日:
2011.09.16
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A method of reducing intraocular pressure in a subject in need of such treatment, comprising administering a therapeutically effective amount of a composition containing a compound of Formula I, its individual enantiomers, its individual diastereoisomers, its hydrates, its solvates, its crystalline forms, its individual isomers, its individual tautomers or a pharmaceutically acceptable salt thereof, wherein R is H or C1-6alkyl； R is H or C1-6alkyl； R is H, C1-6alkyl, heterocycle or aryl； and R is C1-6alkyl, heterocycle or aryl. 2. The method according to claim 1, characterized in that the compound is a compound of Formula II, its individual diastereoisomers, its hydrates, its solvates, its crystalline forms, its individual isomers, its individual tautomers or its pharmaceutically acceptable salt, where R is H or C1-6alkyl； R is H or C1-6alkyl； R is H, C1-6alkyl, heterocycle or aryl； and R is C1-6 alkyl, heterocycle or aryl. 3. The method according to claim 1, characterized in that the compound is a compound of Formula III, its individual diastereoisomers, its hydrates, its solvates, its crystalline forms, its individual isomers, its individual tautomers or its pharmaceutically acceptable salt, where R is H or C1-6alkyl； R is H or C1-6alkyl； R is H, C1-6alkyl, heterocycle or aryl； and R is C1-6 alkyl, heterocycle or aryl. 4. The method according to claim 2, characterized in that R is C1-6alkyl, R is C1-6alkyl, R is H, and R is C1-6alkyl. The method according to claim 2, characterized in that R is methyl, R is methyl, R is H, and R is C1-6alkyl. The method according to claim 2, characterized in that the connection in1. Способ снижения внутриглазного давления у субъекта, нуждающегося в таком лечении, включающий введение терапевтически эффективного количества композиции, содержащей соединение Формулы I, его отдельные энантиомеры, его отдельные диастереоизомеры, его гидраты, его сольваты, его кристаллические формы, его отдельные изомеры, его отдельные таутомеры или ег
